AAV8 capsid variable regions at the two-fold symmetry axis contribute to high liver transduction by mediating nuclear entry and capsid uncoating
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چکیده
منابع مشابه
Long-distance correlations of rhinovirus capsid dynamics contribute to uncoating and antiviral activity.
Human rhinovirus (HRV) and other members of the enterovirus genus bind small-molecule antiviral compounds in a cavity buried within the viral capsid protein VP1. These compounds block the release of the viral protein VP4 and RNA from inside the capsid during the uncoating process. In addition, the antiviral compounds prevent "breathing" motions, the transient externalization of the N-terminal r...
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The small size, and thus coding capacity, of viral genomes necessitates the repetitive use of identical building blocks in constructing the viral capsid. This genetic economy gives rise to highly symmetric structures, typically with either helical or icosahedral geometries. Assembly of symmetric viral capsids is believed to proceed via “conformational switching” of individual protein subunits (...
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ژورنال
عنوان ژورنال: Virology
سال: 2014
ISSN: 0042-6822
DOI: 10.1016/j.virol.2014.02.017